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KMID : 0861019980130010095
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Korea Journal of Herbology
1998 Volume.13 No. 1 p.95 ~ p.117
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Effects of Herba Pyrolae Extract on the Immune Inflammatory Responses and the Functions of Immunocytes in the Mouse
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Abstract
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This study was carried out to know the effects of Herba Pyrolae on the immune-inflammatio and the function or immunocytes of the mouse. To analyse the in vivo effects of Herba Pyrolae on the innate immunity, phagocytic ability and reactive oxygen intermediates(ROIs) formatio of the [eritoneal macropharges were measured, and in vivo specific immunities were analysed by measuring the antibody formatio against sheep red blood cells(SRBCs) and contact hypersensitivity reaction(CHR) against dinitrofluorobenzene(DNFB). The effects of Herba Pyrolae on the antibody forming cells were measured by the enumeration of rosette forming cells. The effects of Herba Pyrolae on the target cell killing were mersured by cytotoxicity of natural killer(NK)cells on the YAC-1 cells and of killer(K)cells in the antibody coated target cells.
The in vivo effects of Herba Pyrolae adminstration on the immune system could be summerized as follows;
1. The adminstration of Herba Pyrolae enhanced the antibody dependent cellular cytotoxicity of K cells on the antibody-coated target cells.
2. The adminstration of Herba Pyrolae increased the tumor cell killing capacity of the NK cells.
3. The adminstration of Herba Pyrolae enhanced the phagocytic activity of peritoneal macrophages.
4. The adminstration of Herba Pyrolae decreased the CHR against DNFB slightly.
5. The adminstration of Herba Pyrolae enhanced the antibody (hemolysin and hemagglutinin) production against SRBCs.
6. The adminstration of Herba Pyrolae increased the rosette forming cells with SRBC in a dose dependent fashion.
7. The adminstration of Herba Pyrolae enhanced the capacity of phagocytes to produce ROIs slightly in a dose dependent fashion.
The above enhancing effects of Herba Pyrolae adminstration on the function of immunocytes without affecting immuno mediated imflammation might be useful for the pervention and treatment of the various immune associated disorder.
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